Scratch

This is how i would do it

1. Using 3D frames like reiners
You simply import all the frames (I suggest doing it in bulk by click and dragging from out side scratch) remove the backgrounds (if there are any) then you come to the programing.
If you are doing it the way you said, you only need a few of the diffrent directions supplied by Reiner, (He/she gives you 8 diffrent directions) , You then just do it like a simple X scroller.